University of Connecticut University of UC Title Fallback Connecticut

Carolyn M. Teschke

TeschkeCarolynCarolyn M. Teschke
Professor

Department of Molecular & Cell Biology
91 North Eagleville Road
Storrs, CT 06269-3125
Phone: (860) 486-4282
Email: carolyn.teschke@uconn.edu Web: http://mcb.uconn.edu/carolyn-teschke/
 
 

Education

  • Post-doctoral training, Massachusetts Institute of Technology
  • Ph.D., Washington State University

 

Research Focus

  • Biochemical, biophysical, and mutational analysis of virus assembly, especially of the thermodynamics of capsid assembly and maturation reactions.
  • The role of the two SecA homologs in protein export in mycobacterium tuberculosis.
  • Protein folding in vivo and in vitro. Interaction of folding intermediates with molecular chaperones.

 

Current Publications

Padilla-Meier GP, Gilcrease EB, Weigele PR, Cortines JR, Siegel M, Leavitt JC, Teschke CM, Casjens SR (2012) “Unraveling the Role of the C-terminal Helix-Turn-Helix of the Coat-binding Domain of Bacteriophage P22 Scaffolding Protein.” J Biol Chem. 2012 Aug 9. [Epub ahead of print]

Teschke CM. (2012) “Themes and Variations of Viral Small Terminase Proteins.” Structure 20(8): 1291-2.

Parent KN, Deedas CT, Egelman EH, Casjens SR, Baker TS, Teschke CM (2012) “Stepwise Molecular Display Utilizing Icosahedral and Helical Complexes of Phage Coat and Decoration Proteins in the Development of Robust Nanoscale Display Vehicles.” Biomaterials 33(22):5628-37. Epub 2012 May 8.

Zlotnick A, Suhanovsky MM, Teschke CM (2012) The Energetic Contributions of Scaffolding and Coat Proteins to the Assembly of Bacteriophage Procapsids.” Virology 428(1):64-9. Epub 2012 Apr 20.

Cortines JR, Weigele PR, Gilcrease EB, Casjens SR, Teschke CM (2011) “Decoding Bacteriophage P22 Assembly: Identification of Two Charged Residues in Scaffolding Protein Responsible for Coat Protein Interaction.” Virology 421(1):1-11. Epub 2011 Oct 4.

Suhanovsky MM, Teschke CM (2011) “Bacteriophage P22 Capsid Size Determination: Roles for the Coat Protein Telokin-like Domain and the Scaffolding Protein Amino-Terminus.” Virology 417(2):418-29. Epub 2011 Jul 23.

Padilla-Meier GP, Teschke CM (2011) “Conformational Changes in Bacteriophage P22 Scaffolding Protein Induced by Interaction with Coat Protein.” J Mol Biol 410(2):226-40. Epub 2011 May 14.

Parent KN, Sinkovits RS, Suhanovsky MM, Teschke CM, Egelman EH, Baker TS. (2010) “Cryo-Reconstructions of P22 Polyheads Suggest that Phage Assembly is Nucleated by Trimeric Interactions Among Coat Proteins.” Phys Biol. 7(4):045004.

Suhanovsky MM, Parent KN, Dunn SE, Baker TS, Teschke CM (2010) “Determinants of Bacteriophage P22 Polyhead Formation: the Role of Coat Protein Flexibility in Conformational Switching.” Mol Microbiol 77(6):1568-82 Epub 2010 Aug 18.

Teschke CM, Parent KN (2010) “Let the Phage do the Work: Using the Phage P22 Coat Protein Structures as a Framework to Understand its Folding and Assembly Mutants.” Virology 401(2):119-30. Epub 2010 Mar 16.