Pimentel T, Yan Z, Hodges RS, Burkhard P. (2009) Peptide nanoparticles as novel immunogens: Design and analysis of a prototype SARS vaccine. Chemical Biology and Drug Design, 73(1):53-61 (MEDLINE)

Schroeder U, Graff A, Buchmeier S, Rigler P, Silvan U, Tropel D, Jockusch BM, Aebi U, Burkhard P, Schoenenberger CA. (2009). Peptide nanoparticles serve as a powerful platform for the immunogenic display of poorly antigenic actin determinants. J Mol Biol. 386(5):1368-81 (MEDLINE)

Raman S, Machaidze G, Lustig A, Olivieri A, Aebi U and Burkhard P. (2009) Design of Peptide Nanoparticles Using Simple Protein Oligomerization Domains. The Open Nanomedicine Journal, 2:15-26 (LINK)

Meier M, Padilla GP, Herrmann H, Wedig T, Hergt M, Patel TR, Stetefeld J, Aebi U, Burkhard P. (2009). Vimentin Coil 1A-A Molecular Switch Involved in the Initiation of Filament Elongation. J Mol Biol. (MEDLINE)

Parry, D.A., Strelkov, S.V., Burkhard P., Aebi U., and Herrmann H. (2007). Towards a molecular description of intermediate filament structure and assembly. Exp Cell Res., 313 (10), 2204-2216. (MEDLINE)

Chattopadhyay, A., Meier, M., Ivaninskii, S., Burkhard, P., Speroni, F., Campanini, B., Bettati, S., Mozzarelli, A., Rabeh, W.M., Li, L., and Cook, P.F. (2007) Structure, Mechanism, and Conformational Dynamics of O-Acetylserine Sulfhydrylase from Salmonella typhimurium: Comparison of A and B Isozymes. Biochemistry, 46 (28), 8315-8330 (MEDLINE)

Stetefeld, J., Jenny, M., and Burkhard, P. (2006). Intersubunit signaling in glutamate-1-semialdehyde-aminomutase. PNAS,  103 (37), 13688-13693 (MEDLINE)

Meier, M., and Burkhard, P. (2006). Statistical analysis of intrahelical ionic interactions in α-helices and coiled coils. J. Struct. Biol.,  155, 116-129 (MEDLINE)

Raman, S.K., Machaidze, G., Lustig, A., Aebi, U. and Burkhard, P. (2006). Structure-based design of peptides that self-assemble into regular polyhedral nanoparticles. Nanomedicine, 2, 95-102 (LINK)

Sanner, M.F., Stolz, M., Burkhard, P., Kong, X., Min, G., Sun, T., Driamov, S., Olson, A.J., Aebi, U., and Stoffler, D. (2005). Visualizing nature at work from the nano to the macro scale.  NanoBiotechnology, 1 (1), 7-22 (LINK)

Appenzeller-Herzog, C., Nyfeler, B., Burkhard, P., Santamaria, I., Lopez-Otin, C., and Hauri, H.P. (2005). Carbohydrate- and Conformation-dependent Cargo Capture for ER-Exit. Mol Biol Cell. 16 (3), 1258-67. (MEDLINE)

Lee, D.L., Ivaninskii, S., Burkhard, P., and Robert S. Hodges, R.S. (2003). Unique stabilizing interactions identified in the two-stranded alpha-helical coiled-coil: Crystal structure of a cortexillin I/GCN4 hybrid peptide.  Protein Science 12 (7), 1395-1405.  (MEDLINE)

Meier, M., Oliveriusova, J., Kraus, J.P., & Burkhard P. (2003). Structural insights into mutations of cystathionine beta-synthase. Biochim Biophys Acta., 1647(1-2):206-13. (MEDLINE)

Hahn, E., Wild, P., Hermanns, U., Sebbel, P., Glockshuber, R., Haner, M., Taschner, N., Burkhard, P., Aebi, U., & Muller, S.A. (2002). Exploring the 3D Molecular Architecture of Escherichia coli Type 1 Pili. J. Mol. Biol., 323 (5), 845-857. (MEDLINE)

Burkhard, P., Ivaninskii, S., & Lustig, A. (2002). Improving coiled-coil stability by optimizing ionic interactions. J. Mol. Biol., 318, (3), 901-910. (MEDLINE)

Meier, M., Lustig, A., Aebi, U., and Burkhard, P. (2002). Removing an interhelical salt bridge abolishes coiled-coil formation in a de novo designed peptide. J. Struct. Biol., 137 (1/2), 65-72. (MEDLINE)

Strelkov, S. V., and Burkhard, P. (2002). Analysis of alpha-helical coiled coils with the program TWISTER reveals a structural mechanism for stutter compensation. J. Struct. Biol., 137 (1/2), 54-64. (MEDLINE)

Smith, T.A., Strelkov, S.V., Burkhard, P., Aebi, U., and Parry, D.A.D. (2002). Sequence comparisons of intermediate filament chains: evidence of a unique functional/structural role for coiled-coil segment 1A and linker L1. J. Struct. Biol., 137 (1/2), 128-145. (MEDLINE)

Strelkov, S., Herrmann, H., Geisler, N., Wedig, T., Zimbelmann, R., Aebi, U. and Burkhard, P. (2002). Conserved segments 1A and 2B of the intermediate filament dimer: their atomic structures and role in filament assembly. EMBO Journal, 21 (6), 1255-1266. (MEDLINE).

Burkhard, P., Dominici, P., Borri-Voltattorni, C., Jansonius, J.N., & Malashkevich, V.N. (2001). Structural insight into Parkinson’s disease treatment gained from drug-inhibited DOPA decarboxylase. Nature Struct. Biol., 8 (11), 963 - 967. (MEDLINE).

         For a comment see Nature Reviews Neuroscience 2 (12), 855

Meier, M., Janosik, M., Kery, V., Kraus, J. & Burkhard, P. (2001). Structure of human cystathionine beta-synthase: A unique pyridoxal 5'-phosphate dependent hemeprotein. EMBO Journal, 20 (15), 3910-3916. (MEDLINE).

De Marco, V., Burkhard, P., Le Bot, N., Vernos, I. & Hoenger, A. (2001). A detailed look into the heterodimer formation of Xklp3A/B, a newly cloned kinesin-II from Xenopus laevis. EMBO Journal, 20 (13), 3370-3379. (MEDLINE)

Tai, C. H., Burkhard, P., Gani, D., Jenn, T., Johnson, C., & Cook, P. F. (2001) Characterization of the Allosteric Anion-Binding Site of O-Acetylserine Sulfhydrylase. Biochemistry, 40, 7446-52. (MEDLINE)

Burkhard, P., Stetefeld, J. & Strelkov, S.V. (2001). Coiled coils: a highly versatile protein folding motif. Trends in Cell Biology, 11, 82-88. (MEDLINE)

Strelkov, S.V., Herrmann, H., Geisler, N., Lustig, A., Ivaninskii, S., Zimbelmann, R., Burkhard, P. & Aebi, U. (2001).  'Divide-and-conquer' crystallographic approach towards an atomic structure of intermediate filaments. J. Mol. Biol., 306, 771-779. (MEDLINE)

Bruno, S., Schiaretti, F., Burkhard, P., Kraus, J.P., Janosik, M. & Mozzarelli, A. (2001). Functional properties of human cystathionine b-synthase crystals. J Biol Chem, 276, 16-19. (MEDLINE)

Janosik, M., Meier, M., Oliveriusova, J., Burkhard, P. & Kraus, J. (2001). Crystallization and preliminary X-ray diffraction analysis of the active core of  human recombinant cystathionine beta-synthase: An enzyme involved in cardiovascular disease. Acta Cryst, D57, 289-291.  (MEDLINE)

Burkhard, P., Meier, M. & Lustig, A. (2000).  Design of a minimal protein oligomerization domain, a structural approach. Protein Science,9, 2294-2301. (MEDLINE)

Von Matt, A., Erhardt, C, Burkhard, P., Metternich, R., Walkinshaw, M. D. & Taparelli, C. (2000). Selective boron-containing thrombin inhibitors - X-ray analysis reveals surprising binding mode. Bioorg. Med. Chem., 8, 2291-2303. (MEDLINE)

Burkhard, P., Tai, C. H., Jansonius, J. N. & Cook, P. F. (2000). Identification of an Allosteric Anion-Binding Site on O-Acetylserine Sulfhydrylase: Structure of the Enzyme with Chloride Bound. J Mol Biol, 303, 279-286.  (MEDLINE)

Meier, M., Bider, M. D., Malashkevich, V. N., Spiess, M. & Burkhard, P. (2000) Crystal structure of the carbohydrate recognition domain of the H1 subunit of the asialoglycoprotein receptor. J Mol Biol, 300, 857-865.  (MEDLINE)

Herrmann, H., Strelkov, S., Feja, B., Rodgers, K. R., Brettel, M., Lustig, A., Haner, M., Parry, D. A. D., Steinert, P. M., Burkhard, P. & Aebi, U (2000). The intermediate filament protein consensus motif of helix 2B: atomic structure and contribution to assembly. J Mol Biol, 298, 817-832.  (MEDLINE)

Burkhard, P., Kammerer, R. A., Steinmetz, M. O., Bourenkov, G. P. & Aebi, U. (2000). The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of inter- and intra-helical salt-bridges. Structure, 8, 223-230.  (MEDLINE)

        For a comment see Nature Struct. Biol., 5, (1998), 762

Burkhard, P., Taylor, P. & Walkinshaw, M. D. (2000). X-ray structures of small ligand-FKBP complexes provide an estimate for hydrophobic interaction energies. J Mol Biol, 295, 953-62.  (MEDLINE)

Malashkevich, V. N., Burkhard, P., Dominici, P., Moore, P. S., Borri Voltattorni, C. & Jansonius, J. N. (1999). Preliminary X-ray analysis of a new crystal form of recombinant pig kidney DOPA decarboxylase. Acta Cryst, D55, 568-70.  (MEDLINE)

Burkhard, P., Tai, C. H., Ristroph, C. M., Cook, P. F. & Jansonius, J. N. (1999). Ligand binding induces a large conformational change in O-acetylserine sulfhydrylase from Salmonella typhimurium. J Mol Biol, 291, 941-53.  (MEDLINE)

Burkhard, P., Hommel, U., Sanner, M. & Walkinshaw, M. D. (1999). The discovery of steroids and other novel FKBP inhibitors using a molecular docking program. J Mol Biol, 287, 853-8.  (MEDLINE)

Mozzarelli, A., Bettati, S., Pucci, A. M., Burkhard, P. & Cook, P. F. (1998). Catalytic Competence of O-Acetylserine Sulfhydrylase in the Crystal Probed by Polarized Absorption Microspectrophotometry. J Mol Biol, 283, 135-146.  (MEDLINE)

Burkhard, P., Steinmetz, M. O., Schulthess, T., Landwehr, R., Aebi, U. & Kammerer, R. A. (1998). Crystallization and preliminary X-ray diffraction analysis of the 190 A long coiled-coil dimerization domain of the actin-bundling protein cortexillin I from Dictyostelium discoideum. J Struct Biol, 122, 293-296.  (MEDLINE)

Burkhard, P., Jagannatha Rao, G. S., Hohenester, E., Schnackerz, K. D., Cook, P.F. & Jansonius, J. N. (1998). Three-dimensional Structure of O-acetylserine Sulfhydrylase from Salmonella typhimurium. J Mol Biol, 283, 121-133.  (MEDLINE)

Burkhard, P., Taylor, P. & Walkinshaw, M. D. (1998). An example of a protein ligand found by database mining: description of the docking method and its verification by a 2.3 A X-ray structure of a thrombin-ligand complex. J Mol Biol, 277, 449-66.  (MEDLINE)

Taylor, P., Mikol, V., Kallen, J., Burkhard, P. & Walkinshaw, M. D. (1996). Conformational polymorphism in peptidic and nonpeptidic drug molecules. Biopolymers, 40, 585-92.  (MEDLINE)
 

Books

Tai, C. T., Burkhard, P., Jansonius, J. N. & Cook, P. F. (2000). Inhibition and structural changes of O-acetylserine sulfhydrylase-A from Salmonella typhimurium upon binding of sulfate and chloride anions. Biochemistry and molecular biology of vitamin B6 and PQQ dependent proteins, 271-276. Birkhäuser Verlag, Basel

Cook, P. F., Jansonius, J. N. & Burkhard, P. (1998). O-acetylserine sulfhydrylase: Mechanism of the alpha, beta-elimination reaction. Steenbock Symposium on Enzymatic Mechanisms