University of Connecticut University of UC Title Fallback Connecticut

Michael J. Pikal

PikalMichaelMichael J. Pikal
Pfizer Distinguished Endowed Chair in Pharmaceutical Technology

Department of Pharmaceutical Sciences
69 North Eagleville Road
Storrs, CT 06269-3092
Phone: (860) 486-3202
Email:  Web:



  • Ph.D. Iowa State University, Physical Chemistry
  • B.A. St. John’s University, Minnesota, Chemistry


Research Focus

  • Lyophilization of proteins and other pharmaceuticals – process, formulation and stability
  • Solid state chemistry of proteins
  • Dynamics in the glassy state and pharmaceutical stability



  • Ebert Prize, 1977
  • Busse Lecturer at the University of Wisconsin, 1983
  • PDA’s “Best Paper of the Year” Award, 1989
  • Eli Lilly & Co. “President’s Award”, 1996
  • Enz Lecturer at the University of Kansas, 1998
  • American Association of Pharmaceutical Scientists (AAPS) Research Achievement Award in Pharmaceutical Technologies, 2001
  • Distinguished Pharmaceutical Scientist Award from the American Association of Pharmaceutical Scientists (AAPS), 2010


Current Publications

Luthra, S.A., Shalaev, E.Y., Medec, A., Hong, J., Pikal, M.J. (2012) “Chemical Stability of Amorphous Materials: Specific and General Media Effects in the Role of Water in the Degradation of Freeze-Dried Zoniporide,” J. Pharm. Sci. 101(9), 3110-3123.

Padilla, A.M., Pikal, M.J. (2011) “The Study of Phase Separation in Amorphous Freeze-Dried Systems, Part 2: Investigation of Raman Mapping as a Tool for Studying Amorphous Phase Separation in Freeze Dried Protein Formulations,” J. Pharm. Sci.100(4), 1467-1474.

Patel, S.M., Pikal, M.J. (2011) “Emerging Freeze-Drying Process Development and Scale-Up Issues,” AAPS PharmSciTech 12(1), 372-378.

Murdande, S.B., Pikal, M.J., Shanker, R.M., Bogner, R.H. (2010) “Solubility Advantage of Amorphous Pharmaceuticals: I. A Thermodynamic Analysis,” J. Pharm. Sci. 99(3), 1254-1264.

Wang, B., Cicerone, M.T., Pikal, M.J. (2010) The Impact of Thermal Treatment on the Stability of Freeze Dried Amorphous Pharmaceuticals: II. Aggregation in an IgG1 Fusion Protein,” J. Pharm. Sci. 99, 683-700.

Abdul-Fattah, A.M., Kalonia, D.S., Pikal, M.J. (2007) “The Challenge of Drying Method Selection for Protein Pharmaceuticals: Product Quality Implications,” J. Pharm. Sci. 96(8), 1886-1916.