University of Connecticut University of UC Title Fallback Connecticut

Jessica Rouge


Dr. Jessica RougeJessica Rouge
Assistant Professor

Department of Chemistry
55 North Eagleville Road, Unit 3060
Storrs, CT 06269-3136
Office: A-417
Phone: (860) 486-4784
Email:    Web:




  • Postdoctoral Fellow, Dept. of Chemistry, Northwestern University, 2013 – 2015
  • Ph.D., Chemistry, University of Colorado, 2012
  • B.S. , Biochemistry, Boston College, 2006


Research Focus

  • Preserving biomolecule structure and function at inorganic nanoparticle surfaces
  • Enzyme-mediated assembly of nanomaterials
  • Nucleic acid aptamer selections for enhanced specificity in binding and catalysis applications
  • siRNA, catalytic nucleic acids and the design of novel drug delivery approaches



  • Pharmaceutical Researchers and Manufacturers of America (PhRMA) Postdoctoral Fellowship in Pharmaceutics (2014)
  • National Research Council (NRC) Postdoctoral Fellowship, National Institute of Standards and Technology (declined) 2012


Current Publications

Soyoung E. Seo, Mary X. Wang, Chad M. Shade, Jessica L. Rouge, Keith Brown and Chad A. Mirkin.  “Modulating the Bond Strength of DNA-Nanoparticle Superlattices.” ACS Nano, 2016, 10, 1771-1779.

Jessica L. Rouge, Timothy M. Sita, Liangliang Hao, Chad A. Mirkin. “Ribozyme-Spherical Nucleic Acids.” J. Am. Chem. Soc. 2015, 137, 10528-10531

Jessica L. Rouge, Liangliang Hao, Xiaochen A. Wu, William E. Briley, and Chad A. Mirkin. “Spherical Nucleic Acids as a Divergent platform for assembling RNA-Nanoparticle constructs through Enzymatic Ligation.” ACS Nano, 2014, 8, 8837-8843.

Jessica L. Rouge, Bruce E. Eaton, Daniel L. Feldheim. “Biomolecules in the Synthesis and Assembly of Materials for Energy Applications.” J. Energy & Environ. Sci. 2011, 4, 398 – 402.

Thomas A. Baker, Jessica L. Rouge, David J. Nesbitt. “Single molecule studies of quantum dot fluorescence intermittency: evidence for both dark and light-assisted blinking dynamics” Mol. Phys., 2009, 107, 1867-1878

Chad J. Dooley, Jessica Rouge, Nan Ma, Michael Invernale and Shana O. Kelley. “Nucleotide-stabilized cadmium sulfide nanoparticles.” J. Mater. Chem., 2007, 17, 1687-1691.