University of Connecticut University of UC Title Fallback Connecticut

Kenneth M. Noll

NollKennethKenneth M. Noll

Department of Molecular & Cell Biology
91 North Eagleville Road
Storrs, CT 06269-3125
Phone: (860) 486-4688
Email: Web:


  • Ph.D. University of Illinois


Research Focus

  • Physiology and evolution of hyperthermophilic organisms.
  • Organisms of the bacterial order thermotogales.
  • Evolution of sugar transporters in this lineage and the horizontal transport of genes encoding transporters between members of the thermotogales and archaea.


Current Publications

“Complete Genome Sequence of the Thermophilic, Piezophilic, Heterotrophic Bacterium Marinitoga Piezophila KA3.” Lucas S, Han J, Lapidus A, Cheng JF, Goodwin LA, Pitluck S, Peters L, Mikhailova N, Teshima H, Detter JC, Han C, Tapia R, Land M, Hauser L, Kyrpides NC, Ivanova N, Pagani I, Vannier P, Oger P, Bartlett DH, Noll KM, Woyke T, Jebbar M. J Bacteriol. 2012 Nov; 194(21):5974-5. doi: 10.1128/JB.01430-12.

“Vitamin B (12) Synthesis and Salvage Pathways Were Acquired by Horizontal Gene Transfer to the Thermotogales.” Swithers KS, Petrus AK, Secinaro MA, Nesbø CL, Gogarten JP, Noll KM, Butzin NC.
Genome Biol Evol. 2012;4(8):730-9. doi: 10.1093/gbe/evs057. Epub 2012 Jul 12.

“Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga Prima MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome to Date.” Zhaxybayeva O, Swithers KS, Foght J, Green AG, Bruce D, Detter C, Han S, Teshima H, Han J, Woyke T, Pitluck S, Nolan M, Ivanova N, Pati A, Land ML, Dlutek M, Doolittle WF, Noll KM, Nesbø CL. Genome Biol Evol. 2012;4(8):700-8. doi: 10.1093/gbe/evs059. Epub 2012 Jul 12.

“Genes for the Major Structural Components of Thermotogales Species’ Togas Revealed by Proteomic and Evolutionary Analyses of OmpA and OmpB homologs.” Petrus AK, Swithers KS, Ranjit C, Wu S, Brewer HM, Gogarten JP, Pasa-Tolic L, Noll KM. PLoS One. 2012;7(6):e40236. doi: 10.1371/journal.pone.0040236. Epub 2012 Jun 29.

“Genome Sequence of Thermotoga SP. Strain RQ2, a Hyperthermophilic Bacterium Isolated From a Geothermally Heated Region of the Seafloor Near Ribeira Quente, the Azores.” Swithers KS, DiPippo JL, Bruce DC, Detter C, Tapia R, Han S, Saunders E, Goodwin LA, Han J, Woyke T, Pitluck S, Pennacchio L, Nolan M, Mikhailova N, Lykidis A, Land ML, Brettin T, Stetter KO, Nelson KE, Gogarten JP, Noll KM.
J Bacteriol. 2011 Oct;193(20):5869-70. doi: 10.1128/JB.05923-11.

“Genome Sequence of Kosmotoga Olearia Strain TBF 19.5.1, a Thermophilic Bacterium With a Wide Growth Temperature Range, Isolated From the Troll B Oil Platform in the North Sea.”
Swithers KS, DiPippo JL, Bruce DC, Detter C, Tapia R, Han S, Goodwin LA, Han J, Woyke T, Pitluck S, Pennacchio L, Nolan M, Mikhailova N, Land ML, Nesbø CL, Gogarten JP, Noll KM.
J Bacteriol. 2011 Oct;193(19):5566-7. doi: 10.1128/JB.05828-11.

“Ligands of Thermophilic ABC Transporters Encoded in a Newly Sequenced Genomic Region of Thermotoga Maritima MSB8 Screened by Differential Scanning Fluorimetry.” Boucher N, Noll KM.
Appl Environ Microbiol. 2011 Sep;77(18):6395-9. doi: 10.1128/AEM.05418-11. Epub 2011 Jul 15.

“Kosmotoga Olearia Gen. Nov., SP. Nov., a Thermophilic, Anaerobic Heterotroph Isolated From an Oil Production Fluid.” Dipippo JL, Nesbø CL, Dahle H, Doolittle WF, Birkland NK, Noll KM.
Int J Syst Evol Microbiol. 2009 Dec;59(Pt 12):2991-3000. doi: 10.1099/ijs.0.008045-0. Epub 2009 Jul 30.

“On the Chimeric Nature, Thermophilic Origin, and Phylogenetic Placement of the Thermotogales.”
Zhaxybayeva O, Swithers KS, Lapierre P, Fournier GP, Bickhart DM, DeBoy RT, Nelson KE, Nesbø CL, Doolittle WF, Gogarten JP, Noll KM. Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5865-70. doi: 10.1073/pnas.0901260106. Epub 2009 Mar 23.

“Evolution of Mal ABC Transporter Operons in the Thermococcales and Thermotogales.”
Noll KM, Lapierre P, Gogarten JP, Nanavati DM. BMC Evol Biol. 2008 Jan 15;8:7. doi: 10.1186/1471-2148-8-7.

G.M. Bollas, S. Papadokonstantakis, J. Michalopoulos, G. Arampatzis, A.A. Lappas, I.A. Vasalos A. Lygeros “Using Hybrid Neural Networks in Scaling-Up an FCC Model form a Pilot to an Industrial Unit,” Chem.Eng.Proc., 2003, 42(8-9), 701.