Yi Zhang

Assistant Professor

Department of Biomedical Engineering


  • Ph.D., Georgia Institute of Technology (2016)
  • B.E., Dalian University of Technology (2011)

Research Summary

  • Neurotechnology development
  • CRISPR-based molecular diagnostics
  • Wearable sensors

Honors and Awards

  • NSF CAREER Award, 2023
  • UConn-AAUP Research Excellence Award –Early Career, 2023
  • UConn BME Early Career Faculty Scholar Award, 2023
  • NIH Brain Initiative R01 Awardee, 2020
  • BMES Career Development Award, Biomedical Engineering Society, 2019
  • Waldemar T. Ziegler Award for Best Research Paper, Georgia Tech, 2015
  • Exemplary Academic Achievement Award, Georgia Tech, 2013


    Google Scholar:  https://scholar.google.com/citations?user=R1Kcul4AAAAJ&hl=en

    Wu, I. Heck, N. Zhang, G. Phaup, X. Zhang, Y. Wu, D. E. Stalla, Z. Weng, H. Sun, H. Li, Z. Zhang, S. Ding, D. P. Li, Y. Zhang*, “Wireless, battery-free push-pull microsystem for membrane-free neurochemical sampling in freely moving animals”, Science Advances 2022, 8, eabn2277.

    Wu, N. Zhang, A. Matarasso, I. Heck, H. Li, W. Lu, G. Phaup, M. J. Schneider, Y. Wu, Z. Weng, H. Sun, Z. Gao, X. Zhang, S. G. Sandberg, D. Parvin, E. Seaholm, S. K. Islam, X. Wang, P. E. M. Phillips, D. C. Castro, S. Ding, D. P. Li, M. R. Bruchas, Y. Zhang*, “Implantable aptamer-graphene microtransistors for real-time monitoring of neurochemical release in vivo”, Nano Letters 2022, 22, 9, 3668–3677.

    Gao, G. Wu, Y. Song, H. Li, Y. Zhang, M. J. Schneider, Y. Qiang, J. Kaszas, Z. Weng, H. Sun, B. D. Huey, R. Y. Lai, Y. Zhang*, “Multiplexed monitoring of neurochemicals via electrografting-enabled site-selective functionalization of aptamers on graphene field-effect transistors”, Analytical Chemistry 2022, 94, 24, 8605–8617.

    Li, J. Yang, G. Wu, Z. Weng, Y. Song, Y. Zhang, J. A. Vanegas, L. Avery, Z. Gao, H. Sun, Y. Chen, K. D. Dieckhaus, X. Gao*, Y. Zhang*, “Amplification-free detection of SARS-CoV-2 and respiratory syncytial virus using CRISPR Cas13a and graphene field-effect transistors”, Angew. Chem. Int. Ed. 2022, 61(32): e202203826. (Hot paper and selected as a back cover)

    Yang, Y. Song, X. Deng, J. A. Vanegas, Z. You, Y. Zhang, Z. Weng, L. Avery, K. D. Dieckhaus, A. Peddi, Y. Gao*, Y. Zhang*, X. Gao*, “Engineered LwaCas13a with enhanced collateral activity for nucleic acid detection”, Nature Chemical Biology 2023, 19, 45–54.

    Zhang, Y. Song, Z. Weng, J. Yang, L. Avery, K. D. Dieckhaus, R. Y. Lai, X. Gao, Y. Zhang*, “A point-of-care microfluidic biosensing system for rapid and ultrasensitive nucleic acid detection from clinical samples”, Lab on a Chip 2023, 23, 3862-3873.

    Weng, Z. You, H. Li, G. Wu, Y. Song, H. Sun, A. Fradlin, C. Neal-Harris, M. Lin, X. Gao*, Y. Zhang*, “CRISPR-Cas12a biosensor array for ultrasensitive detection of unamplified DNA with single-nucleotide polymorphic discrimination”, ACS Sensors 2023, 8, 4, 1489–1499.

    Cao, X. Chen, A. Matarasso, Z. Wang, Y. Song, G. Wu, X. Zhang, H. Sun, X. Wang, M. R. Bruchas, Y. Li*, Y. Zhang*, “Covalently attached slippery surface coatings to reduce protein adsorptions on poly(dimethylsiloxane) planar surfaces and 3D microfluidic channels”, ACS Applied Materials & Interfaces 2023, 15, 7, 9987–9995.

    Weng, Z. You, J. Yang, N. Mohammad, M. Lin, Q. Wei, X. Gao*, Y. Zhang*, “CRISPR-Cas biochemistry and CRISPR-based molecular diagnostics”, Angew. Chem. Int. Ed. 2023, 62(17), e202214987.

    Li, G. Wu, Z. Weng, H. Sun, R. Nistala, Y. Zhang*, “Microneedle-based potentiometric sensing system for continuous monitoring of multiple electrolytes in skin interstitial fluids”, ACS Sensors 2021, 6 (6), 2181-2190.


    Yi Zhang
    Contact Information
    Mailing Address25 King Hill Road, Unit 3136, Storrs, CT 06269-3136
    Office LocationScience 1 - MZ1012