Guoan Zheng

Associate Professor

Department of Biomedical Engineering

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Education

• B.S., Zhejiang University M.S., California Institute of Technology
• Ph.D.,California Institute of Technology

Research Summary

The research of the Smart Imaging Laboratory is focused on the development of novel imaging/sensing tools to tackle measurement problems in biology, medicine, and metrology. The major techniques that are under development include gigapixel microscopy platforms, super-resolution florescence imaging approaches, 3D tomography imaging, ePetri dish and related lab-on-a-chip platforms, surface-plasmon-enabled imaging devices, and other novel imaging techniques. In particular, the Fourier Ptychography approach developed by our group represents a new way of tackling microscopy by transforming a physical optical problem to a computational problem. Through this reduction, we can push the performance of standard imaging systems beyond their physical limitations. We have demonstrated the use of Fourier ptychography for high-resolution gigapixel imaging, quantitative phase imaging, spectral multiplexing, adaptive imaging, super-resolution fluorescence imaging, 3D holographic imaging, incoherent photographic imaging, and remote sensing. More information about current projects can be found at: Smart imaging lab at UConn: https://sites.google.com/view/smartimaging/home/

Awards and Honors

• Caltech Demetriades Thesis Prize, 2013
• Phi-Tau-Phi Scholarship, Phi-Tau-Phi Scholastic Honor Society, 2012
• Lemelson-MIT Caltech Student Prize, Kirsch Auditorium, MIT Stata Center, 2011

Publications

Pengming Song, Chengfei Guo*, Shaowei Jiang, Tianbo Wang, Patrick Hu, Derek Hu, Zibang Zhang, Bin Feng, and Guoan Zheng*, “Optofluidic ptychography on a chip,” Lab on a Chip (2021).

(Highlighted by Editor’s pick) Shaowei Jiang, Chengfei Guo, Patrick Hu, Derek Hu, Pengming Song, Tianbo Wang, Zichao Bian, Zibang Zhang, and Guoan Zheng*, “High-throughput lensless whole slide imaging via continuous height-varying modulation of a tilted sensor,” Optics Letters, 46(20), 5212 (2021). (pdf)

Shaowei Jiang, Chengfei Guo*, Zichao Bian, Ruihai Wang, Jiakai Zhu, Pengming Song, Patrick Hu, Derek Hu, Zibang Zhang, Kazunori Hoshino, Bin Feng, Guoan Zheng*, “Ptychographic sensor for large-scale lensless microbial monitoring with high spatiotemporal resolution,” Biosensors and Bioelectronics, 113699 (2021).

(Cover paper) Shaowei Jiang, Chengfei Guo*, Pengming Song, Niyun Zhou, Zichao Bian, Jiakai Zhu, Ruihai Wang, Pei Dong, Zibang Zhang, Jun Liao, Jianhua Yao, Bin Feng, Michael Murphy, and Guoan Zheng*, “Resolution-Enhanced Parallel Coded Ptychography for High-Throughput Optical Imaging,” ACS Photonics (2021).

(Invited) Shaowei Jiang, Guoan Zheng, “Effective color transfer enables rapid computational microscopy for digital pathology,” Science China Physics, Mechanics & Astronomy, 64, 114231 (2021).

Yongbing Zhang, Xu Chen, Bowen Li, Shaowei Jiang, Terrance Zhang, Xu Zhang, Xi Yuan, Peiwu Qin, Guoan Zheng, and Xiangyang Ji, “Accelerated Phase Shifting for Structured Illumination Microscopy based on Deep Learning,” IEEE Transactions on Computational Imaging, 7, 700-712 (2021). DOI: 10.1109/TCI.2021.3093788.

Jongchan Park, David J. Brady, Guoan Zheng, Lei Tian, Liang Gao, “Review of bio-optical imaging systems with a high space-bandwidth product,” Advanced Photonics, 3(4), 044001 (2021).

Changchun Lu, You Zhou, Yanxun Guo, Shaowei Jiang, Zibang Zhang, Guoan Zheng, and Jingang Zhong, “Mask-modulated lensless imaging via translated structured illumination,” Optics Express, 29 (8), 12491-12501, (2021).

Zichao Bian, Tiantian Guo, Shaowei Jiang, Longtu Chen, Jia Liu, Guoan Zheng* and Bin Feng*, “High-throughput functional characterization of visceral afferents by optical recordings from thoracolumbar and lumbosacral dorsal root ganglia,” Frontiers in Neuroscience, 15, 657361, (2021).

Meng Li, Liheng Bian, Guoan Zheng, Andrew Maiden, Yang Liu, Yiming Li, Qionghai Dai, and Jun Zhang, “Single-pixel ptychography“, Optics Letters, 46(6), (2021).

(Cover paper) Guoan Zheng*, Cheng Shen, Shaowei Jiang, Pengming Song, and Changhuei Yang*, “Concept, implementations and applications of Fourier ptychography,” Nature Reviews Physics, 3, 207-223 (2021). (supplementary note; data and code download; free-to-read version of the paper).