Laijun Lai

Research Professor

Department of Allied Health Sciences

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Education

• B.S., Medicine, Shanghai Medical University, China, 1984
• M.D. Pathology, Fujian Medical University, China, 1991

Research Interests

• Use of stem cell technology and gene engineering approaches to prevent or treat autoimmune diseases such as multiple sclerosis (MS).
• Development of gene engineering approaches to enhance anti-tumor immunity and treat cancer.
• Use of stem cell technology to model and treat genetic diseases such as DiGeorge Syndrome (DGS).

Publications

Han F, Hu R, Su M, Yu Y, Yang H, and Lai L. A human recombinant IL-7/HGF
hybrid cytokine enhances antitumor immunity in Mice. Am J Cancer Res.
2017;7(8):1714-1723

Su M, Hu R, Song Y, Liu Y, and Lai L. Targeted deletion of c-Met in thymic epithelial
cells leads to an autoimmune phenotype. Immunol Cell Biol. 2018, 96(2):229-235,

Su M, Lin Y, Cui C, Tian X, Lu X, He Z, Lai L. ESC-derived thymic epithelial cells
expressing MOG prevents EAE by central and peripheral tolerance mechanisms. Cell
Immunol. 2017, 322:84-91.

Cui C, Tian X, Lin Y, Su M, Chen Q, Wang SY, Lai L. In vivo administration of
recombinant BTNL2-Fc fusion protein ameliorates graft-versus-host disease in mice. Cell
Immunol. 2018. Epub 2018/11/06. doi: 10.1016/j.cellimm.2018.10.008. PubMed PMID:
30389093.

Cui C, Su M, Lin Y, Lai L. A CD300c-Fc Fusion Protein Inhibits T Cell Immunity.
Frontiers in Immunology. 2018;9(2657). doi: 10.3389/fimmu.2018.02657.

Tian X, Cui C, Lin Y, Su M, Lai L. BTNL2-Ig protein attenuates type 1 diabetes in NOD
mice. Adv Healthc Mater. 2019 May;8(9):e1800987.

Su M, Lin Y, He Z, Lai L. Transplantation of MHC-mismatched Mouse Embryonic Stem
Cell-Derived Thymic Epithelial Progenitors Prevents Autoimmune Diabetes. Stem Cell
Res Ther. 2019 Aug 6;10(1):239.

Lin Y, Cui C, Su M, Tian X, Huang Y, Zhao J, Lai L. Skint8, a Novel B7 Family-
Related Molecule, Negatively Regulates T Cell Responses. J Immunol. 2019 Jul
15;203(2):400-407.

Su M, Lin Y, Cui C, Tian X, Lai L. ERMAP is a B7 family-related molecule which
negatively regulates T cell and macrophage responses. Cellular & Molecular

Zhao J, Su M, Lin Y, Liu H, He Z, Lai L. Administration of amyloid precursor protein
gene deleted mouse ESC-derived thymic epithelial progenitors attenuates Alzheimer’s
pathology. Frontiers in Immunology, accepted