Xudong Yao

Associate Professor

Department of Chemistry

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Education

• Postdoctoral Associate, University of Maryland, 1999-2002
• Ph.D. University of Maryland Baltimore County
• M.S. Nanjing University, China
• B.S. Nanjing University, China

Research Interests

Proteomic chemistry. Novel and broadly applicable technologies for complex “-ome” analysis, currently focusing on the method and technology development of ultrathroughput mass spectrometry. Mass spectrometry of membrane proteins and proteomes. Systems proteomics of cellular signal transduction.

Publications

“Single-Sequence Identification of Modified Peptides: A One-Pot Method Using Homologous Biotinyl Azides.” L. Wang, C. Punzalan, B. Bajrami, L. Riel, B. Deng, A. Howell, X. Yao, ChemRxiv, DOI: 10.26434/chemrxiv-2023-8w3vf

“Measurement and utilization of the proteomic reactivity by mass spectrometry.” Punzalan, C.; Wang, L.; Bajrami, B.; Yao, X. Mass Spectrometry Reviews, 2023, DOI:10.1002/mas.21837.

“Network Topology of Biological Aging and Geroscience-Guided Approaches to COVID-19.”  Landay A, Bartley JM, Banerjee D, Hargis G, Haynes L, Keshavarzian A, Kuo C-L, Kwon OS, Li S, Li S, Oh J, Ozbolat IT, Ucar D, Xu M, Yao X, Unutmaz D and Kuchel GA. Front. Aging 2021, 2:695218. doi: 10.3389/fragi.2021.695218

“α‐Methylene‐β‐lactone scaffold for developing chemical probes at the two ends of the selectivity spectrum.”  Wang, L., L. P. Riel, B. Bajrami, B. Deng, A. R. Howell, X. Yao. ChemBioChem. 2021, 22, 505-515 (Cover Feature).

“Treasure hunt for peptides with undefined chemical modifications: Proteomics identification of differential albumin adducts of 2‐nitroimidazole‐indocyanine green in hypoxic tumor.” Wang, L.; Dietz, C.; Zhou, F.; Erfanzadeh, M.; Zhu, Q.; Smith, M.B.; Yao, X. J Mass Spectrom 2020, 55, e4376

“Quantitative Proteomics in Development of Disease Protein Biomarkers.” Lei Wang, Adam J. McShane, Mary Joan Castillo, Xudong Yao, “Proteomic and Metabolomic Approaches to Biomarker Discovery, 2ed” edited by Haleem J. Issaq, Timothy D. Veenstra, 2019.

“Tuning of human MAIT cell activation by commensal bacteria species and MR1-dependent T-cell presentation.” Cihan Tastan, Ece Karhan, Wei Zhou, Elizabeth Fleming, Anita Y. Voigt, Xudong Yao, Lei Wang, Meghan Horne, Lindsey Placek, Lina Kozhaya, Julia Oh & Derya Unutmaz. Mucosal Immunology, 2018, 11(6), 1591-1605.

“Directed Evolution of a Picomolar Affinity High Specificity Antibody Targeting Phosphorylated Tau.” D. Li, L. Wang, B.F. Maziuk, X. Yao, B. Wolozin, Y.K.Cho. J Biol Chem. 2018, pii: jbc.RA118.003557. doi: 10.1074/jbc.RA118.003557.

“Determining Linear Free Energy Relationships in Peptide Fragmentation Using Derivatization and Targeted Mass Spectrometry.” Yuanyuan Shen, Reza Nemati, Lei Wang, and Xudong Yao, Anal. Chem. 2018, 90 (3), pp 1587-1594; DOI: 10.1021/acs.analchem.7b02191.